Volume 4 Issue 1
Research Article: Heat Shock Transcription Factor (HSF) is Down-Regulated in a Drosophila Model of Parkinson's Disease
Pokrzywa M1#, Pawelek K1 and Pernilla Wittung-Stafshede2*#
Alpha-Synuclein (aS) aggregation and deposition into Lewy bodies is involved in Parkinson's disease (PD) progression, but the underlying mechanisms are unclear. Therefore, animal models such as Drosophila with high genetic power are of interest. Here we show that protein levels of the fly heat shock transcription factor HSF (corresponding to HSF-1 in humans) are reduced as a function of increased human aS levels in a Drosophila PD model. This result implies that PD like Huntington's disease involves HSF-1 degradation and, moreover, that fruit flies can act as a model system for further studies dissecting the pathways connecting HSF, aS and PD.
Cite this Article: Pokrzywa M, Pawelek K, Wittung-Stafshede P. Heat Shock Transcription Factor (HSF) is Down-Regulated in a Drosophila Model of Parkinson's Disease. Alzheimers Parkinsons Dis Open Access. 2018;4(1): 001-004.
Published: 17 April 2018
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